01 / Reached
215
Screener responses
Vasomotor symptoms recruitment
TIOGA-VMS-08 · site 001, Atlanta GA
Recruitment funnel
Cumulative since 7 Jun 202602 / Referred
88
Referred to the site
03 / Open
15
Still with the site
04 / Excluded
39
Not eligible
05 / Enrolled
4
Randomised
+10 new referrals this week · site 00121 of 88 unreachable · 24% · 4 enrolled to date
Why applicants failed pre-screening
Disqualifying answersCounts shown; each question was answered by a different number of people.
Taking medication for hot flashes30
Not a woman aged 40–6228
Fewer than 40 episodes a week25
Blood pressure not controlled21
Not generally in good health15
Fewer than 6 episodes a day15
Current cancer diagnosis13
Not in late perimenopause or menopause11
Also recorded: liver, kidney or seizure conditions 7; resting heart rate of 100 or more 5; abnormal Pap, breast or mammogram result 3. A disqualifying answer did not stop the screener, so these counts overlap and do not sum to the 130 who dropped out before consent.
Why sites turned referrals down
39 decisions- Prohibited medication — SSRI, SNRI, gabapentin, pregabalin, clonidine
- 12
- Duplicate, test or previously screened record
- 6
- Menstrual criteria not met
- 6
- Uncontrolled blood pressure
- 5
- Mental health — anxiety, depression, elevated GAD-7 or PHQ-9
- 3
- Symptom threshold or diary compliance
- 2
- Cardiovascular or renal condition
- 2
- Hormonal treatment for hot flashes
- 1
- Age outside range
- 1
- Declined to proceed
- 1
- Total
- 39
Site performance
Site 001 · Atlanta GA- Referred
- 88
- Open
- 15
- Unreachable
- 21
- Not eligible
- 39
- Declined
- 9
- Enrolled
- 4
All sites totals are identical · cumulative since 7 Jun 2026
Contact effort
88 referrals- Phone calls2.4 per referral
- 213
- Text messages1.0 per referral
- 90
- Emailschannel effectively unused
- 1
- All attempts3.5 per referral
- 304
Outcome and contact effort by status
All 88 referrals| Status | Referrals | Share | Calls | Texts | Emails | Attempts each |
|---|---|---|---|---|---|---|
| Not eligible | 39 | 44.3% | 59 | 10 | 1 | 1.8 |
| Contact not responding | 21 | 23.9% | 87 | 64 | 0 | 7.2 — highest cost, no outcome |
| Eligible, considering joining | 12 | 13.6% | 34 | 7 | 0 | 3.4 — live pipeline |
| Eligible, not joining | 5 | 5.7% | 9 | 1 | 0 | 2.0 |
| Enrolled | 4 | 4.5% | 10 | 3 | 0 | 3.2 |
| Decided not to join | 4 | 4.5% | 10 | 3 | 0 | 3.2 |
| Awaiting first site contact | 2 | 2.3% | 0 | 0 | 0 | 0.0 — received 12 and 13 Sep |
| Contact in process | 1 | 1.1% | 4 | 2 | 0 | 6.0 |
| All referrals | 88 | 100% | 213 | 90 | 1 | 3.5 |